Allergic Rhinitis and its Impact on Asthma (ARIA)

The international ARIA guidelines on the pharmacological management of allergic rhinitis now include Dymista®.3

Ground breaking grading of recommendations3

The original 2010 ARIA guidelines were the first evidence-based recommendations in allergy to follow the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. In the GRADE system, recommendations are classed as “strong” or “conditional”, depending on the guideline panel’s confidence that following the recommendation would be more beneficial than harmful to patients.

The ARIA guideline panel included allergists, ear-nose-throat specialists, pulmonologists, general practitioners, and paediatricians.

The guidelines are aimed primarily at primary care clinicians, school nurses, pharmacists, specialists in allergy and clinical immunology, general internists managing patients with allergic rhinitis, and paediatricians.

Summary of recommendations for combination of an intranasal H1-antihistamine (INAH)3

In patients with seasonal allergic rhinitis (SAR), we suggest either a combination of an INCS with an INAH (Dymista®) or an INCS alone (conditional recommendation - moderate certainty of evidence).

In patients with perennial allergic rhinitis (PAR), we suggest either a combination of an INCS with an INAH (Dymista®) or an INCS alone (conditional recommendation - very low certainty of evidence).

In patients with SAR, we suggest a combination of an INCS with an INAH (Dymista®) rather than an INAH alone (conditional recommendation - low certainty of evidence).

INCS: intranasal corticosteroid; INAH: intranasal antihistamine

Dymista® is indicated for relief of symptoms of moderate to severe seasonal and perennial allergic rhinitis if monotherapy with either intranasal antihistamine or glucocorticoid is not considered sufficient.4


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