Dual action combination

Dual action combination

It is important to remember that Dymista® contains two active ingredients, fluticasone propionate, an intranasal steroid and azelastine an intranasal antihistamine

Antihistamines work quickly to alleviate the immediate symptoms of allergic rhinitis (itching, sneezing, running). Steroids work on the later phase reaction

In addition to azelastine's antihistaminic effects, it has also been shown to have a number of other potentially important attributes, including effects on cytokines, adhesion molecules and inflammatory cells1

Fluticasone propionate is highly selective agonist at glucocorticoid receptor, thereby producing anti-inflammatory and vasoconstriction effects impacting the later phase allergic reaction. Fluticasone propionate in Dymista® exerts a topical effect without systemic side effects due to low bioavailability2

Improved outcomes when using combination products are well accepted and apply to all diseases. Having to take one single device improves compliance and adherence with the medication and patients should be reminded to take Dymista® as directed.

chart

Dymista® spray pattern

The specific formulation and nozzle design of Dymista produces a large fine mist plume

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Experts Corner

Click below to hear about the dual action of Dymista® from leading key opinion leaders in allergic rhinitis

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    Clinical Papers

References

  1. Horak. Effectiveness of twice daily azelastine nasal spray in patients with seasonal allergic rhinitis Ther Clin Risk Manag 2008 Oct; 4(5): 1009–1022.
  2. Sudding GK, Kariyawasam HH, Scadding G, el al. BSACl guideine for the diagnosis and management of allergic and non-allergic rhinitis (Revised Edition 2017; First edition 2007) Clin Exp Allergy. 2017;47:856-889.

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