
Dual action combination
It is important to remember that Dymista® contains two active ingredients, fluticasone propionate, an intranasal steroid and azelastine an intranasal antihistamine
Antihistamines work quickly to alleviate the immediate symptoms of allergic rhinitis (itching, sneezing, running). Steroids work on the later phase reaction
In addition to azelastine's antihistaminic effects, it has also been shown to have a number of other potentially important attributes, including effects on cytokines, adhesion molecules and inflammatory cells1
Fluticasone propionate is highly selective agonist at glucocorticoid receptor, thereby producing anti-inflammatory and vasoconstriction effects impacting the later phase allergic reaction. Fluticasone propionate in Dymista® exerts a topical effect without systemic side effects due to low bioavailability2
Improved outcomes when using combination products are well accepted and apply to all diseases. Having to take one single device improves compliance and adherence with the medication and patients should be reminded to take Dymista® as directed.

Dymista® spray pattern
The specific formulation and nozzle design of Dymista produces a large fine mist plume
Click to watch videoFurther Your Understanding
Click on one of the below links to discover more information about Dymista®, including Flow to use Dymista®, guidelines, clinical papers and request materials.
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Allergic Rhinitis
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Impact of Rhinitis
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Onset
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Treatment
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Guidelines
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Clinical Papers
References
- Horak. Effectiveness of twice daily azelastine nasal spray in patients with seasonal allergic rhinitis Ther Clin Risk Manag 2008 Oct; 4(5): 1009–1022.
- Sudding GK, Kariyawasam HH, Scadding G, el al. BSACl guideine for the diagnosis and management of allergic and non-allergic rhinitis (Revised Edition 2017; First edition 2007) Clin Exp Allergy. 2017;47:856-889.
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