British Society of Allergy and Clinical Immunology (BSACI)

Dymista® is now included in the BSACI guidelines on the diagnosis and management of allergic and non-allergic rhinitis. The BSACI guidelines have been accredited from NICE and the accreditation is valid until 30 January 20231

Rigorous development process1

These guidelines represent the primary clinical recommendations for the treatment of allergic rhinitis in the UK. They were compiled by committee members, experts and reviewers in consultation with all BSACI members. Recommendations are evidence graded, and where evidence was lacking, a consensus was reached among the experts on the committee.

The draft guidelines were amended by the Standards of Care Committee (SOCC), according to a NICE-accredited process.

Summary of recommendations for Dymista®

13.2 INS and topical H1-antihistamine combination1

  • Dymista® leads to greater symptom improvement than using either agent alone in seasonal allergic rhinitis (SAR) (Grade A).
  • The combination approach leads to clinical improvement of symptoms days earlier than seen with azelastine or fluticasone propionate monotherapy.
  • Ocular symptoms of allergy were better treated with the combination spray rather than fluticasone propionate or azelastine alone.
  • Efficacy over fluticasone propionate is demonstrated in perennial allergic rhinitis (PAR).

13.4 Place in therapy1

Combination of topical antihistamine (AH) with intranasal corticosteroids (INS) (Dymista®) should be used in patients when symptoms remain uncontrolled on AH or INS monotherapy or on a combination of oral AH plus INS.

DYMISTA®’S PLACE IN THERAPY IS INDICATED IN THE BSACI TREATMENT ALGORITHM FOR RHINITIS1

Dymista® Treatment Algorithm for Rhinitis

IN: intranasal; OC: oral corticosteroids; AH: antihistamine; LTRA: leukotriene receptor antagonist

Additional therapies can be accomplished using two different medications, or a combination treatment in one device. There is, as yet, no comparative evidence on which to base this choice; however, concordance appears more likely when the regime is simple.

Adapted from Scadding, et al. 2017.1

References

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